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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CENPF All Species: 11.52
Human Site: S2996 Identified Species: 21.11
UniProt: P49454 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49454 NP_057427.3 3210 367764 S2996 S K Q D S R G S P L L G P V V
Chimpanzee Pan troglodytes XP_001171549 3114 357698 S2900 S K Q D S R G S P L L D P V V
Rhesus Macaque Macaca mulatta XP_001105956 3113 357422 S2899 S K P D S R G S P L L D P V V
Dog Lupus familis XP_852813 1449 166096 K1241 F E N L L Q E K E Q E K V Q M
Cat Felis silvestris
Mouse Mus musculus
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510329 2965 340022 L2746 S Q P V K R T L R S S P S Q C
Chicken Gallus gallus O42184 1433 161009 S1225 E R A S L Q K S I S D T S A L
Frog Xenopus laevis P85120 2058 236320 A1850 Q A L S P H G A M G S R G N S
Zebra Danio Brachydanio rerio XP_002665261 2708 311087 S2500 K N Q L K Q L S T Q T K T P K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VJE5 1690 189046 D1482 A E Y Q K V I D E M D D A A S
Honey Bee Apis mellifera XP_001120388 2064 240016 I1856 E T E I D K D I L D D C N E Y
Nematode Worm Caenorhab. elegans P02566 1966 225108 N1758 A D L D E T L N E Y K A A E E
Sea Urchin Strong. purpuratus XP_796801 3636 416057 A3281 N N V S P P A A A K H T V P E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P25386 1790 206434 S1582 R I E A K S G S E L E T V K Q
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 95.8 91.4 32.8 N.A. N.A. N.A. N.A. 50.5 20.4 21.5 31.3 N.A. 21.3 22.9 20.1 22
Protein Similarity: 100 96.4 93.8 39.1 N.A. N.A. N.A. N.A. 67.5 32.4 38.6 51.2 N.A. 35.2 41.3 36.4 43.7
P-Site Identity: 100 93.3 86.6 0 N.A. N.A. N.A. N.A. 13.3 6.6 6.6 13.3 N.A. 0 0 6.6 0
P-Site Similarity: 100 93.3 86.6 20 N.A. N.A. N.A. N.A. 20 26.6 13.3 20 N.A. 20 13.3 20 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 21.7 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 36.5 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 20 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 16 8 8 8 0 0 8 16 8 0 0 8 16 16 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 8 % C
% Asp: 0 8 0 31 8 0 8 8 0 8 24 24 0 0 0 % D
% Glu: 16 16 16 0 8 0 8 0 31 0 16 0 0 16 16 % E
% Phe: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 39 0 0 8 0 8 8 0 0 % G
% His: 0 0 0 0 0 8 0 0 0 0 8 0 0 0 0 % H
% Ile: 0 8 0 8 0 0 8 8 8 0 0 0 0 0 0 % I
% Lys: 8 24 0 0 31 8 8 8 0 8 8 16 0 8 8 % K
% Leu: 0 0 16 16 16 0 16 8 8 31 24 0 0 0 8 % L
% Met: 0 0 0 0 0 0 0 0 8 8 0 0 0 0 8 % M
% Asn: 8 16 8 0 0 0 0 8 0 0 0 0 8 8 0 % N
% Pro: 0 0 16 0 16 8 0 0 24 0 0 8 24 16 0 % P
% Gln: 8 8 24 8 0 24 0 0 0 16 0 0 0 16 8 % Q
% Arg: 8 8 0 0 0 31 0 0 8 0 0 8 0 0 0 % R
% Ser: 31 0 0 24 24 8 0 47 0 16 16 0 16 0 16 % S
% Thr: 0 8 0 0 0 8 8 0 8 0 8 24 8 0 0 % T
% Val: 0 0 8 8 0 8 0 0 0 0 0 0 24 24 24 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 0 0 0 0 0 0 8 0 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _